Nasal cavity, paranasal sinuses, nasopharynx
Sinonasal carcinoma
Low grade (seromucinous) adenocarcinoma

Author: Abul Ala Syed Rifat Mannan, M.D. (see Authors page)
Editor: Songyang Yuan, M.D., Ph.D.

Revised: 21 May 2018, last major update August 2013

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Low grade seromucinous adenocarcinoma

Cite this page: Mannan, A.A.S.R. Low grade (seromucinous) adenocarcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/nasalLGseromucinous.html. Accessed October 17th, 2018.
Definition / general
Epidemiology
  • Wide age range, mean age of 37 - 53 years at presentation
  • No gender predilection
Sites
  • Anywhere in sinonasal tract; but nasal cavity is most commonly affected, followed by ethmoid and maxillary sinuses (J Clin Pathol 2009;62:1085)
Etiology
  • No known risk factors, predisposing conditions or environmental exposures identified
Clinical features
  • Presents primarily with nasal obstruction and epistaxis
  • Pain is uncommon
Prognostic factors
  • Excellent prognosis
  • Most patients have localized disease at presentation, local recurrence has been reported but metastasis is rare
  • Rare reports of death due to local invasion (Cancer 1982;50:312)
Case reports
Treatment
  • Complete surgical excision
  • Radiotherapy reserved for extensive disease
Clinical images

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Eustachian tube tumor

Gross description
  • Variable; well demarcated to poorly defined, flat to exophytic or papillary growth with tan / white to pink color and friable to firm consistency
Microscopic (histologic) description
  • Morphologically heterogeneous
  • Mostly glandular or papillary patterns (Head Neck Pathol 2007;1:38)
  • Other morphologic variants include clear cell (Arch Otolaryngol Head Neck Surg 2002;128:441), cribriform, mucinous, trabecular
  • Commonly compact acini, back to back glands, cystic dilatation; some cases show intraglandular mucin
  • Tumor cells exhibit uniform morphology, with abundant cytoplasm, mild to moderate nuclear atypia, inconspicuous nucleoli
  • Rare mitotic figures, no atypical mitoses, no necrosis
Microscopic (histologic) images

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Bland serous glands

Complex papillary growth pattern

Tubulopapillary pattern

Eustachian tube tumor


TTF1+ case

Differential diagnosis