Nasal cavity, paranasal sinuses, nasopharynx
Hematologic conditions
NK / T cell lymphoma, nasal type

Author: Nat Pernick, M.D. (see Authors page)

Revised: 2 November 2018, last major update November 2004

Copyright: (c) 2004-2018,, Inc.

PubMed Search: NK / T cell lymphoma, nasal type[TI]

Cite this page: Pernick, N. NK / T cell lymphoma, nasal type. website. Accessed December 17th, 2018.
Definition / general
Case reports
  • Radiotherapy, chemotherapy
Gross description
  • Usually perforated nasal septum, perforated palate, erosion of antral bone or ulceration of skin overlying nose or antrum
Microscopic (histologic) description
  • Polymorphic infiltrate of lymphocytes (small to large), plasma cells, neutrophils and scattered atypical lymphoid cells with perinuclear clearing
  • Frequent angiolymphatic invasion and necrosis, although vessel is usually infiltrated by atypical lymphocytes with no neutrophils and no fibrinoid necrosis present
  • Often epitheliotropism
  • Frequent histiocytes with erythrophagocytosis
Microscopic (histologic) images

Images hosted on PathOut server:

Case of the Week #101:

Extensive necrosis

Pleomorphic tumor cells with necrosis

Tumor cells invade vessel walls without fibrinoid necrosis

Keratin-, with positive internal control




EBV+ (by ISH)


Images hosted on other servers:

Various images

Prior to radiotherapy

Postradiotherapy cardiac involvement

Positive stains
Negative stains
  • CD3 (nuclear), CD16 (positive on histiocytes but not tumor cells), CD57
  • CD79a (usually)
Molecular / cytogenetics description
  • No T cell receptor gene rearrangement, no immunoglobulin light or heavy chain rearrangements
Molecular / cytogenetics images

Images hosted on other servers:

Monoclonal proliferation of EBV+ cells

Differential diagnosis