Nasal cavity, paranasal sinuses, nasopharynx
Sinonasal carcinoma
Squamous cell carcinoma, nonkeratinizing (cylindrical / transitional)


Topic Completed: 1 November 2013

Revised: 3 June 2019

Copyright: 2004-2019, PathologyOutlines.com, Inc.

PubMed Search: Cylindrical transitional cell carcinoma

Rifat Mannan, M.D.
Songyang Yuan, M.D., Ph.D.
Page views in 2018: 1,396
Page views in 2019 to date: 1,245
Cite this page: Mannan R, Yuan S. Squamous cell carcinoma, nonkeratinizing (cylindrical / transitional). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/nasalcylindrical.html. Accessed November 15th, 2019.
Definition / general
  • Rare variant of sinonasal squamous cell carcinoma in sinonasal tract
  • Usually develops de novo, rarely arises from preexisting inverted papilloma
Terminology
  • Also known as nonkeratinizing squamous cell carcinoma, transitional carcinoma, Schneiderian carcinoma, Ringertz carcinoma, respiratory epithelial carcinoma, cylindrical (transitional) cell carcinoma
Epidemiology
  • Constitutes 10% of malignant tumors of sinonasal tract and about 30% of squamous cell carcinomas in this region
  • Predominantly affects males in seventh decade
Sites
  • Maxillary antrum is most common site, followed by lateral nasal wall and ethmoid sinus
Etiology
Clinical features
  • Nasal obstruction, rhinorrhea and epistaxis are common
  • Advanced cases may present with proptosis, diplopia or lacrimation
Prognostic factors
  • Better prognosis than keratinizing squamous cell carcinoma
Case reports
Treatment
  • Surgical resection is treatment of choice
  • Possibly radiotherapy (Cancer 1970;25:50)
Gross description
  • May be an exophytic, fungating or papillary mass
Microscopic (histologic) description
  • Papillary, ribbon-like or plexiform patterns, frequently with central necrosis
  • Resembles urothelial (transitional) carcinoma
  • Usually invades underlying tissue with a pushing margin
  • Tumor cells are medium to large, with cylindrical or basaloid morphology, marked nuclear atypia and brisk mitotic activity
  • Squamous differentiated cells are frequently seen but tumor is devoid of significant keratinization
  • Occasional mucus containing cells can be seen
Microscopic (histologic) images

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Transitional (cylindrical) cell carcinoma in sinonasal papilloma

Positive stains
Negative stains
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