Nasal cavity, paranasal sinuses, nasopharynx
Other tumors
Desmoplastic small round cell tumor

Topic Completed: 1 November 2004

Revised: 19 February 2019

Copyright: 2004-2018,, Inc.

PubMed Search: Desmoplastic small round cell tumor nasal
Page views in 2018: 366
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Cite this page: Pernick N. Desmoplastic small round cell tumor. website. Accessed May 26th, 2019.
Definition / general
  • Rare, aggressive tumor, usually in abdomen of adolescents and young adults
  • 80% men
Case reports
Microscopic (histologic) description
  • Nests of cells with variable amphophilic cytoplasm and hyperchromatic nuclei surrounded by desmoplastic stroma
  • Highly invasive with necrosis and bone destruction
  • Scattered mitotic figures
  • No glandular differentiation
  • No rosettes
Positive stains
Molecular / cytogenetics description
  • t(11;22)(p13;q12) by RT-PCR (Wilms tumor suppressor gene - Ewing sarcoma gene transcript)
Differential diagnosis
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