Nasal cavity, paranasal sinuses, nasopharynx
Other tumors
Desmoplastic small round cell tumor

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 May 2018, last major update November 2004

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Desmoplastic small round cell tumor nasal

Cite this page: Pernick, N. Desmoplastic small round cell tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/nasaldesmoplasticsmall.html. Accessed September 21st, 2018.
Definition / general
  • Rare, aggressive tumor, usually in abdomen of adolescents and young adults
  • 80% men
Case reports
Microscopic (histologic) description
  • Nests of cells with variable amphophilic cytoplasm and hyperchromatic nuclei surrounded by desmoplastic stroma
  • Highly invasive with necrosis and bone destruction
  • Scattered mitotic figures
  • No glandular differentiation
  • No rosettes
Positive stains
Molecular / cytogenetics description
  • t(11;22)(p13;q12) by RT-PCR (Wilms tumor suppressor gene - Ewing sarcoma gene transcript)
Differential diagnosis