Nasal cavity, paranasal sinuses, nasopharynx
Inflammatory / infectious lesions
Eosinophilic angiocentric fibrosis

Author: Nat Pernick, M.D. (see Authors page)

Revised: 17 May 2018, last major update November 2004

Copyright: (c) 2004-2018,, Inc.

PubMed Search: Eosinophilic angiocentric fibrosis nasal

Cite this page: Pernick, N. Eosinophilic angiocentric fibrosis. website. Accessed November 21st, 2018.
Definition / general
  • Very rare; unknown cause
  • May be mucosal counterpart of granuloma faciale
  • Involves any portion of upper respiratory tract, often nasal septum and sinus mucosa
  • Usually women, mean age 44 years
Case reports
  • Corticosteroids, resection
Microscopic (histologic) description
  • Thick collagen bundles, perivascular onion skin fibrosis with eosinophil rich inflammatory infiltrate
  • No granulomas, no necrosis, no vasculitis
Microscopic (histologic) images

Images hosted on other servers:

1. Concentric fibrosis
2. Onion skin fibrosis

Differential diagnosis
  • Granuloma faciale: inflammatory vascular reaction with facial papules, neutrophilic and eosinophilic infiltrate, vasculitis with fibrinoid material in vessel walls