Nasal cavity, paranasal sinuses, nasopharynx
Other tumors
Giant cell reparative granuloma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 May 2018, last major update November 2004

Copyright: (c) 2004-2018,, Inc.

PubMed Search: Giant cell reparative granuloma nasal

Cite this page: Pernick, N. Giant cell reparative granuloma. website. Accessed November 18th, 2018.
Definition / general
  • Similar to aneurysmal bone cyst
  • Rarely occurs after dental extraction
  • 15 - 26% recur
Microscopic (histologic) description
  • Spindled, ovoid or round histiocytes-like cells in well vascularized fibrous stroma
  • Cells have 1 - 3 nuclei and may form giant cells with 10 - 20 nuclei that aggregate in groups of 6 - 12 cells
  • Giant cells tend to invade and line vascular channels
  • Lesions contain metaplastic woven bone and lamellar bone lined by osteoblasts and occasionally osteoclasts
  • Prominent extravasation of blood, numerous mitotic figures