Nasal cavity, paranasal sinuses, nasopharynx
Inflammatory / infectious lesions
Idiopathic midline destructive disease

Author: Nat Pernick, M.D. (see Authors page)

Revised: 31 October 2018, last major update November 2004

Copyright: (c) 2004-2018,, Inc.

PubMed Search: Idiopathic midline destructive disease nasal

Cite this page: Pernick, N. Idiopathic midline destructive disease. website. Accessed November 21st, 2018.
Definition / general
  • Diagnosis of exclusion
Gross description
  • Usually perforated nasal septum, perforated palate, erosion of antral bone or ulceration of skin overlying nose or antrum
Microscopic (histologic) description
  • Acute and chronic inflammatory cells with variable necrosis
  • May have multinucleated giant cells or granulomas
  • No atypical lymphocytes, no fibrinoid necrosis of vessels, no prominent eosinophils
Differential diagnosis