Nasal cavity, paranasal sinuses, nasopharynx
Other tumors
Leiomyoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 May 2018, last major update November 2004

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Leiomyoma nasal

Cite this page: Pernick, N. Leiomyoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/nasalleiomyoma.html. Accessed July 17th, 2018.
Definition / general
  • Very rare
  • Mean age 40 years, range 20 - 67 years
  • Good prognosis with complete surgical excision, even if uncertain malignant potential or low grade leiomyosarcoma
Gross description
  • Usually small (~2 cm)
Microscopic (histologic) description
  • Low cellularity, no nuclear pleomorphism, no infiltrative growth, no mitotic activity
Microscopic (histologic) images

Images hosted on other servers:

A: leiomyoma with perivascular fascicles of smooth muscle cells, no atypia, no mitotic figures
B: smooth muscle tumor of uncertain malignant potential (SMTUMP) with perivascular growth
C: SMTUMP shows moderate cellularity and nuclear atypia; D: low grade leiomyosarcoma with hypercellularity,
moderate atypia, 10 MF/10 HPF; E: MIB1 (5%) for SMTUMP; F: MIB1 (20%) for low grade leiomyosarcoma

Negative stains
Differential diagnosis
  • Leiomyosarcoma: > 4 mitotic figures/10 high power fields, moderate nuclear pleomorphism, moderate to high cellularity, focal infiltrative growth, occasional tumor necrosis
  • Smooth muscle tumor of uncertain malignant potential: 1 - 4 MF/10 HPF, mild to moderate pleomorphism