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General
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Proposed staging:

Treatment
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Case reports
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Gross description
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Micro description
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Micro images
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Spindled cells invading cranial bone


A - gross of hard palate pigmented macular lesion
B - tumor presents as nasal septum polyp
C - hard palate in situ melanoma
D - maxillary antrum melanoma
E - epithelioid melanoma in maxillary mucosa with moderate cytoplasm, pleomorphic nuclei, prominent nucleoli
F - nasal cavity sarcomatoid melanoma with cells resembling vacuolated lipoblasts


A - poorly differentiated/undifferentiated tumor
B - pseudopapillary pattern
C - S100+ only rarely (not typical)
D - HMB45+
E - MelanA+
F - tyrosinase+
G - microphthalmia transcription factor+


Figure 1 - MRI shows large nasal mass involving right maxillary sinus and extending into right orbit, temporal and pterygoid fossa
2 - polypoid fragments of respiratory mucosa with submucosal cellular tumor
3 - necrosis and angiocentric tumor cells
4 - cells have moderate cytoplasm, round nuclei, inconspicuous nucleoli, but high mitotic rate

Positive stains
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Negative stains
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Differential diagnosis
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Additional references
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End of Nasal cavity > Other tumors > Melanoma



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