Nasal cavity, paranasal sinuses, nasopharynx
Nasopharyngeal carcinoma
Papillary adenocarcinoma of nasopharynx

Author: Abul Ala Syed Rifat Mannan, M.D. (see Authors page)
Editor: Songyang Yuan, M.D., Ph.D.

Revised: 4 October 2018, last major update April 2014

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Papillary adenocarcinoma of nasopharynx

Cite this page: Mannan, A.A.S.R. Papillary adenocarcinoma of nasopharynx. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/nasalpapillaryadenocarcinoma.html. Accessed December 17th, 2018.
Definition / general
  • Low grade primary adenocarcinoma of nasopharynx, derived from surface epithelium
Epidemiology
  • Uncommon tumor of nasopharynx
  • Median age 37 years but occurs over a wide age range
  • Not associated with wood dust exposure or other known factors
  • Not related to EBV
  • No gender predilection
Sites
  • May occur anywhere in nasopharynx but preferred locations are roof, posterior wall and lateral wall
Clinical features
  • Nasal obstruction is most common presenting symptom
  • Tumors usually remain confined within nasopharynx
  • Excellent prognosis
  • Slow growing and indolent
  • Rarely recurs (if incomplete excision)
  • No metastases reported to date
Case reports
Treatment
  • Complete surgical excision is usually curative
Clinical images

Images hosted on other servers:

Well defined large polypoid tumor

Gross description
  • Soft, exophytic mass with papillary appearance
  • Size can vary from a few millimeters to 3.0 cm
Microscopic (histologic) description
  • Infiltrative tumor with papillary and glandular growth patterns
    • Papillary structures are complex with arborization and fibrovascular cores
    • Glandular growth has cribriform or back to back glands
  • Lined by cuboidal or columnar cells with pink cytoplasm and round / oval nuclei that are variably clear or hyperchromatic
  • Mild to moderate nuclear pleomorphism, no / rare nucleoli
  • Mitotic figures are inconspicuous
  • Occasionally psammoma bodies may be present
  • May be focal necrosis
  • No angiolymphatic invasion or perineural invasion
Microscopic (histologic) images

Images hosted on other servers:

H&E

Papillae and glands

TTF1, CK19, vimentin, EMA

Strong TTF1 nuclear staining

Positive stains
Negative stains
Differential diagnosis