Nasal cavity, paranasal sinuses, nasopharynx
Hematologic conditions

Author: Nat Pernick, M.D. (see Authors page)

Revised: 22 May 2018, last major update November 2004

Copyright: (c) 2004-2018,, Inc.

PubMed Search: Plasmacytoma[TI] nasal[TIAB]

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Cite this page: Pernick, N. Plasmacytoma. website. Accessed January 22nd, 2019.
Definition / general
  • Nasal cavity and paranasal sinuses are common site of extramedullary plasmacytoma
  • May present as soft, bleeding mass
  • Usually age 40+ years; 80% male
  • Most patients, even with solitary tumors, develop myeloma up to 10 years later
  • Radiation therapy
Microscopic (histologic) description
  • Monomorphic infiltrate of immature plasma cells
  • Usually no other inflammatory cells
Positive stains
  • Light chain monoclonality, EMA, variable CD45
Differential diagnosis