Nasal cavity, paranasal sinuses, nasopharynx
Hematologic conditions

Topic Completed: 1 November 2004

Revised: 19 February 2019

Copyright: 2004-2018,, Inc.

PubMed Search: Plasmacytoma[TI] nasal[TIAB]
Page views in 2018: 444
Page views in 2019 to date: 128
Cite this page: Pernick N. Plasmacytoma. website. Accessed April 26th, 2019.
Definition / general
  • Nasal cavity and paranasal sinuses are common site of extramedullary plasmacytoma
  • May present as soft, bleeding mass
  • Usually age 40+ years; 80% male
  • Most patients, even with solitary tumors, develop myeloma up to 10 years later
  • Radiation therapy
Microscopic (histologic) description
  • Monomorphic infiltrate of immature plasma cells
  • Usually no other inflammatory cells
Positive stains
  • Light chain monoclonality, EMA, variable CD45
Differential diagnosis
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