Nasal cavity, paranasal sinuses, nasopharynx
Inflammatory / infectious lesions
Nasal polyps, cystic fibrosis

Topic Completed: 1 November 2004

Revised: 25 April 2019

Copyright: 2004-2019,, Inc.

PubMed search: Nasal polyps[TI] cystic fibrosis

See also: General, Angiectatic, Antrochoanal, Atypical stromal cells, Inflammatory

Nat Pernick, M.D.
Page views in 2018: 597
Page views in 2019 to date: 463
Cite this page: Pernick, N. Nasal polyps, cystic fibrosis. website. Accessed August 25th, 2019.
Definition / general
  • Must rule out cystic fibrosis in any child with nasal polyps
  • Present in 20% with cystic fibrosis
  • May arise up to 12 years before clinical diagnosis; rarely is initial manifestation of disease in adults
Microscopic (histologic) description
  • Similar to inflammatory polyps but no basement membrane thickening, no submucosal hyalinization, no / rare stromal eosinophils
  • May have large cystic glands with inspissated mucin in lumina
  • Mucous glands, cysts and mucous contain predominantly acid mucin
Positive stains
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