Nasal cavity, paranasal sinuses, nasopharynx
Inflammatory / infectious lesions
Nasal polyps, inflammatory


Topic Completed: 1 November 2004

Revised: 9 October 2019

Copyright: 2004-2019, PathologyOutlines.com, Inc.

PubMed search: Nasal polyp[TI] inflammatory[TIAB]

Nat Pernick, M.D.
Page views in 2018: 15,454
Page views in 2019 to date: 16,037
Cite this page: Pernick, N. Nasal polyps, inflammatory. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/nasalpolypinflammatory.html. Accessed November 14th, 2019.
Definition / general
  • Most common type of nasal polyp
  • Due to recurrent attacks of rhinitis (allergic, inflammatory)
  • Most people with polyps are NOT atopic; only 0.5% with atopy develop polyps
  • Usually ages 30 years or older (rarely < age 20 years)
  • Often recurs after surgery
  • Often associated with asthma, chronic rhinitis, aspirin intolerance (14%)
Gross description
  • Usually multiple and bilateral and involve nasal cavity and paranasal sinuses
  • Have translucent, moist or edematous cut surface (opaque areas may represent papilloma)
  • Broad base of attachment is present
  • Usually not destructive
Microscopic (histologic) description
  • Respiratory epithelium, often with squamous metaplasia, edematous and loose stroma with hyperplastic mucous glands, inflammatory infiltrate (lymphocytes, plasma cells, eosinophils, neutrophils, mast cells)
  • Mucosa may be ulcerated or infected
  • Basal membrane may be thickened
  • May have bizarre stromal cells (large and pleomorphic) due to reactive changes
  • May have prominent glandular component
Microscopic (histologic) images

Images hosted on other servers:

Respiratory mucosa
with edematous stroma
with numerous eosinophils
and plasma cells

Differential diagnosis
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