Nasal cavity, paranasal sinuses, nasopharynx
Other tumors
Psammomatoid ossifying fibroma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 24 May 2018, last major update November 2004

Copyright: (c) 2004-2018,, Inc.

PubMed Search: Psammomatoid ossifying fibroma nasal

Cite this page: Pernick, N. Psammomatoid ossifying fibroma. website. Accessed September 21st, 2018.
Definition / general
  • Distinctive solitary fibro-osseous lesion of young persons that affects orbit and paranasal sinuses
  • Affects extragnathic craniofacial bones (periorbital, frontal and ethmoid)
  • Slowly progressive, may invade and destroy surrounding tissue and cause bony erosion
  • Tends to recur after excision
Radiology description
  • Xray: expansile well circumscribed, partially radiolucent lesion surrounded by a thick bony wall
Case reports
  • Complete surgical excision
Microscopic (histologic) description
  • Numerous small, round ossicles (psammomatoid bodies) embedded in cellular fibrous stroma and within bony trabeculae
  • Stroma may be loose and fibroblastic or intensely cellular without collagen
  • Contains variably shaped cells with indistinct cytoplasmic borders and basophilic nuclei
  • Variable giant cells, stroma with cystic degeneration
  • Rare mitotic figures
  • No anaplasia, no necrosis
Microscopic (histologic) images

Images hosted on other servers:

Fig 1: mass in right ethmoid sinus
Fig 2: numerous small, round ossicles
resembling psammoma bodies in collagenous
cellular stroma with uniform, stellate cells

Differential diagnosis
  • Central cementifying fibroma: benign odontogenic jaw lesion, usually ages 20 - 39 years, female, has cementicles (related to dental cementum), not ossicles