Nasal cavity, paranasal sinuses, nasopharynx
Developmental / heterotopias / pseudotumors / cysts
Respiratory epithelial adenomatoid hamartoma

Topic Completed: 1 November 2004

Revised: 3 June 2019

Copyright: 2004-2019,, Inc.

PubMed Search: Respiratory epithelial adenomatoid hamartoma nasal

Nat Pernick, M.D.
Page views in 2018: 3,020
Page views in 2019 to date: 3,701
Cite this page: Pernick N. Respiratory epithelial adenomatoid hamartoma. website. Accessed December 12th, 2019.
Definition / general
  • First described in 1995
  • Usually posterior nasal septum of men
  • Median age 58 years (range 27 - 82 years)
  • Associated with chronic rhinosinusitis
  • Complete excision
  • Usually doesn't recur
Gross description
  • Polypoid or exophytic, rubbery, tan-brown, up to 4.9 cm but without destructive growth
Microscopic (histologic) description
  • Proliferation of glandular spaces lined by ciliated epithelium or goblet cells
  • Glands have thick, eosinophilic basement membranes
  • Background resembles inflammatory polyp due to vascularization, edema and chronic inflammatory cells
Microscopic (histologic) images

Images hosted on other servers:

Numerous glands lined by
ciliated respiratory epithelium
(resembles inverted papilloma)

Each gland is surrounded by
an eosinophilic, thick
basement membrane

Contributed by Semir Vranić, M.D., Ph.D.

Various images


Differential diagnosis
  • Adenocarcinoma: back to back glands, occasional nuclear pleomorphism, prominent mitotic activity, perineural invasion, desmoplastic stroma
  • Inflammatory polyp: has fewer glands
  • Inverted papilloma: usually on lateral nasal wall not nasal septum, usually hyperplastic squamous epithelium with only few goblet cells, thin basement membrane, no / rare mucoserous glands
Back to top