Nasal cavity, paranasal sinuses, nasopharynx
Other tumors
Respiratory epithelial adenomatoid hamartoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 25 May 2018, last major update November 2004

Copyright: (c) 2004-2018,, Inc.

PubMed Search: Respiratory epithelial adenomatoid hamartoma nasal

Cite this page: Pernick, N. Respiratory epithelial adenomatoid hamartoma. website. Accessed October 19th, 2018.
Definition / general
  • First described in 1995
  • Usually posterior nasal septum of men
  • Median age 58 years (range 27 - 82 years)
  • Associated with chronic rhinosinusitis
  • Complete excision
  • Usually doesn't recur
Gross description
  • Polypoid or exophytic, rubbery, tan-brown, up to 4.9 cm but without destructive growth
Microscopic (histologic) description
  • Proliferation of glandular spaces lined by ciliated epithelium or goblet cells
  • Glands have thick, eosinophilic basement membranes
  • Background resembles inflammatory polyp due to vascularization, edema and chronic inflammatory cells
Microscopic (histologic) images

Images hosted on other servers:

Numerous glands lined by
ciliated respiratory epithelium
(resembles inverted papilloma)

Each gland is surrounded by
an eosinophilic, thick
basement membrane

Contributed by Semir Vranić, M.D., Ph.D.

Various images


Differential diagnosis
  • Adenocarcinoma: back to back glands, occasional nuclear pleomorphism, prominent mitotic activity, perineural invasion, desmoplastic stroma
  • Inflammatory polyp: has fewer glands
  • Inverted papilloma: usually on lateral nasal wall not nasal septum, usually hyperplastic squamous epithelium with only few goblet cells, thin basement membrane, no / rare mucoserous glands