Oral cavity
Human immunodeficiency virus (HIV)

Topic Completed: 1 August 2012

Revised: 30 January 2019

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PubMed Search: Human immunodeficiency virus[TI] HIV oral[TI] free full text[sb]

Patricia DeVilliers D.D.S., M.S.
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Cite this page: DeVilliers P, Thakral C Human immunodeficiency virus (HIV). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavityHIV.html. Accessed April 6th, 2020.
Definition / general
  • Associated with opportunistic infections, herpes simplex virus, Candida, fungi, Kaposi sarcoma, hairy leukoplakia
  • Lymphoid hyperplasia of Waldeyer ring is frequent symptomatic complication, often with HIV+, EBV- multinucleated giant cells in crypt or surface epithelium (Hum Pathol 1999;30:1383, Mod Pathol 2000;13:1293)
Microscopic (histologic) description
  • Adenoids and tonsils: florid follicular hyperplasia, follicle lysis, attenuated mantle zone, multinucleated giant cells adjacent to surface or tonsillar crypt epithelium (Am J Surg Pathol 1996;20:572)
  • May have marked lymphoid depletion with no germinal centers, plasmacytosis and stromal vascular proliferation
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