Human immunodeficiency virus (HIV)
Reviewer: Patricia DeVilliers, D.D.S., M.S. (see Reviewers page)
Revised: 3 October 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.
● Associated with opportunistic infections, herpes simplex virus, Candida, fungi, Kaposi’s sarcoma, hairy leukoplakia
● Lymphoid hyperplasia of Waldeyer’s ring is frequent symptomatic complication, often with HIV+, EBV- multinucleated giant cells in crypt or surface epithelium (Hum Pathol 1999;30:1383, Mod Pathol 2000;13:1293)
● Adenoids and tonsils - florid follicular hyperplasia, follicle lysis, attenuated mantle zone, multinucleated giant cells adjacent to surface or tonsillar crypt epithelium (Am J Surg Pathol 1996;20:572)
● May have marked lymphoid depletion with no germinal centers, plasmacytosis and stromal vascular proliferation
Multinucleated giant cells in Waldeyer’s ring
End of Oral cavity > Infectious > Human immunodeficiency virus (HIV)
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