Oral cavity
Inflammatory (noninfectious) lesions
Melkersson-Rosenthal syndrome

Author: Charu Thakral, M.D. (see Authors page)

Revised: 17 April 2018, last major update March 2013

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Melkersson-Rosenthal syndrome oral cavity

Cite this page: Thakral, C. Melkersson-Rosenthal syndrome. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavityMRsyndrome.html. Accessed October 17th, 2018.
Definition / general
  • Rare neurological disorder characterized by orofacial swelling (usually of upper lip), peripheral facial nerve paralysis and plicated tongue
  • No known cause; onset in childhood or early adolescence
  • After recurrent attacks, swelling may persist and eventually become permanent
  • Lips become hard, cracked and fissured with a reddish brown discoloration
  • Cheilitis granulomatosa: may be a variant, sometimes considered to be a monosymptomatic form of Melkersson-Rosenthal syndrome
Case reports
Treatment
  • Symptomatic
Clinical images

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Diffuse swelling of lip

Microscopic (histologic) description
  • Granulomatous inflammation of lip stroma
Microscopic (histologic) images

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Nonnecrotizing granulomas

Giganto-epithelioid granuloma

Differential diagnosis