Table of Contents
Definition / general | Case reports | Treatment | Clinical images | Microscopic (histologic) description | Microscopic (histologic) images | Differential diagnosisCite this page: Thakral C. Melkersson-Rosenthal syndrome. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/oralcavityMRsyndrome.html. Accessed March 28th, 2024.
Definition / general
- Rare neurological disorder characterized by orofacial swelling (usually of upper lip), peripheral facial nerve paralysis and plicated tongue
- No known cause; onset in childhood or early adolescence
- After recurrent attacks, swelling may persist and eventually become permanent
- Lips become hard, cracked and fissured with a reddish brown discoloration
- Cheilitis granulomatosa: may be a variant, sometimes considered to be a monosymptomatic form of Melkersson-Rosenthal syndrome
Case reports
- 14 year old girl with monosymptomatic form of Melkersson-Rosenthal syndrome (Rom J Morphol Embryol 2012;53:851)
- 30 year old man with Down syndrome (Dermatol Online J 2012;18:7)
Treatment
- Symptomatic
Microscopic (histologic) description
- Granulomatous inflammation of lip stroma
Microscopic (histologic) images
Differential diagnosis