Oral cavity
Other carcinomas (non salivary gland)

Topic Completed: 1 November 2013

Revised: 4 February 2019

Copyright: (c) 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Adenosquamous carcinoma oral cavity
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Cite this page: Pernick N Adenosquamous. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavityadenosquamous.html. Accessed March 25th, 2019.
Definition / general
  • Rare, aggressive
  • Derived from minor (but not major) salivary glands and ducts
  • > 90% men, mean age 58 years old (range 32 - 99 years)
  • Sites: tongue, floor of mouth, nasal cavity and larynx
  • Metastases: 70 - 80% incidence even with primaries < 1 cm; variable histology
  • Surgical resection with neck dissection
  • 5 year survival: 25%
Gross description
  • 2 mm to 1 cm erythroplakic ulcer or indurated submucosal nodule
Microscopic (histologic) description
  • Adenocarcinoma, squamous cell carcinoma and mixtures resembling mucoepidermoid carcinoma
  • May have multifocal carcinoma in situ involving salivary gland ducts, upward extension of intraductal carcinoma to involve mucosal epithelium
  • Composed of glassy squamous cells; commonly perineural invasion and widespread invasion of submucosa
Positive stains
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