Oral cavity & oropharynx
Squamous cell carcinoma: variants
Basaloid squamous cell carcinoma


Topic Completed: 1 November 2013

Revised: 22 May 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Basaloid squamous cell carcinoma[TI] oral
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Cite this page: Pernick N. Basaloid squamous cell carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavitybasaloidscc.html. Accessed May 23rd, 2019.
Definition / general
  • Uncommon, < 200 cases reported
  • Median age 62 years (range 27 - 88 years), 88% male, 92% smokers and 88% drinkers
  • Sites: base of tongue, tonsil, hypopharynx; also other sites outside upper aerodigestive tract
  • Aggressive with 68% having regional metastases at presentation, 77% stage III / IV, median survival 18 months
  • Metastases to lung
Case reports
Treatment
  • Radical surgery, radiation therapy or chemotherapy
Microscopic (histologic) description
  • Lobules, nests or cribriform patterns of small basaloid cells with peripheral palisading and a thick basement membrane
  • Cells have minimal cytoplasm, are moderately pleomorphic with hyperchromatic nuclei and often abrupt transition to squamous epithelium
  • Single cell necrosis and comedonecrosis are common; often contiguous with carcinoma in situ in surface epithelium
  • Frequent mitotic activity, stroma often hyalinized or myxoid; variable pseudoglandular spaces resembling adenoid cystic carcinoma
  • Rarely has spindle cell component (Arch Pathol Lab Med 1995;119:181)
Positive stains
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