Oral cavity
Minor salivary gland tumors / lesions
Clear cell carcinoma - hyalinizing type

Topic Completed: 1 May 2013

Revised: 4 March 2020

Copyright: 2004-2020, PathologyOutlines.com, Inc.

PubMed Search: Clear cell carcinoma hyalinizing type

Nella Cristina Fernandez, M.D.
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Cite this page: Fernandez NC. Clear cell carcinoma - hyalinizing type. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavityclearcellcarcinomasalivary.html. Accessed March 31st, 2020.
Definition / general
  • Clear cell adenocarcinoma; hyalinizing clear cell carcinoma
  • Most cases occur in oral cavity (> 80%), usually tongue or hard palate, less common in parotid
Clinical features
Prognostic factors
  • Necrosis or increased mitoses are not correlated with recurrence, aggressive behavior or metastatic disease
  • Metastases or local recurrences have been reported in approximately 1/3 (Head and Neck Pathol 2009;3:179)
Gross description
  • Firm, rubbery, elastic, with varied color including white, tan, red and grey
  • 0.5 - 10 cm, mean 2.6 cm (Head and Neck Pathol 2009;3:179)
  • Usually poorly circumscribed and infiltrative
Microscopic (histologic) description
  • Monomorphic glycogen rich clear cells in cords, nests, islands or trabeculae within a hyalinized stroma, with infiltrative margins
  • Minority of cells have eosinophilic cytoplasm
  • Eccentric, round nuclei with small nucleoli
  • Myxoid stromal changes can be seen
  • Inflammatory infiltrate composed of lymphocytes and plasma cells
  • Variable lymphoid follicles with germinal centers
  • Rare mitosis
  • Perineural invasion common (36%) (Head and Neck Pathol 2009;3:179)
Microscopic (histologic) images

Images hosted on other servers:

Hyalinizing stroma

Prominent cytoplasmic clearing

Cytoplasmic glycogen

Positive cytokeratin AE1 / AE3

Contributed by Nella Cristina Fernandez, M.D.

Low power, base of tongue lesion

Infiltrative margins and lymphocytic infiltrate

Cells display small eccentric nuclei

Stroma can show myxoid areas

Hyalinized stroma with cords of clear cells

Some cells show eosinophilic cytoplasm

Positive stains
Negative stains
Electron microscopy description
Molecular / cytogenetics description
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