Oral cavity
Inflammatory (noninfectious) lesions
Crohn's disease

Author: Charu Thakral, M.D. (see Authors page)

Revised: 17 April 2018, last major update February 2013

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Crohn's disease[TI] oral cavity[mh]

Cite this page: Thakral, C. Crohn's disease. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavitycrohns.html. Accessed July 18th, 2018.
Definition / general
  • Initial presentation may be in oral cavity and pharynx
  • 6% have oral lesions at some time (lip, gingiva, vestibular sulci, buccal mucosa)
  • Pyostomatitis vegetans: rare oral lesion associated with inflammatory bowel disease that may precede intestinal involvement; characterized by erythematous, thickened oral mucosa with multiple pustules and superficial erosions; usually peripheral eosinophilia
Clinical images

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Superficial ulcerations in vestibulum oris

Pustules

Oral ulcerations

Microscopic (histologic) description
  • Edema, ulcers, papillary hyperplastic mucosa, dilation of lymphatics, chronic inflammatory infiltrate, giant cells and rarely noncaseating granulomas
Microscopic (histologic) images

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Mononuclear infiltrates and small, noncaseating granulomas