Oral cavity
Other benign tumors / conditions
Crystal storing histiocytosis

Author: Charu Thakral, M.D. (see Authors page)

Revised: 18 April 2018, last major update June 2013

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Crystal storing histiocytosis

See also: Hematology - crystal storing histiocytosis, Lung - nontumor - crystal storing histiocytosis
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Cite this page: Thakral, C. Crystal storing histiocytosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavitycrystalhistiocytosis.html. Accessed January 22nd, 2019.
Definition / general
  • Rare; crystalline material accumulates in cytoplasm of histiocytes; usually kappa light chain origin
  • Typically associated with disorders that express monoclonal immunoglobulins such as myeloma, lymphoplasmacytic lymphoma, monoclonal gammopathy of undetermined significance
Case reports
Microscopic (histologic) description
  • Histiocytes filled with nonbirefringent eosinophilic crystals
  • Lymphocytes and plasma cells also present
Microscopic (histologic) images

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Eosinophilic histiocytes

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Immunoglobulin stains

Positive stains
  • Crystals are typically monoclonal, immunoreactive with kappa or lambda light chain and gamma heavy chain
  • CD68+ histiocytes
Electron microscopy description

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Dense crystals