Oral cavity
Other benign tumors / conditions
Crystal storing histiocytosis

Author: Charu Thakral, M.D. (see Authors page)

Revised: 2 November 2016, last major update June 2013

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PubMed Search: Crystal storing histiocytosis

Related topics: Hematology - Crystal storing histiocytosis, Lung-nontumor - Crystal storing histiocytosis
Cite this page: Crystal storing histiocytosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavitycrystalhistiocytosis.html. Accessed February 19th, 2018.
Definition / general
  • Rare; crystalline material accumulates in cytoplasm of histiocytes; usually kappa light chain origin
  • Typically associated with disorders that express monoclonal immunoglobulins such as myeloma, lymphoplasmacytic lymphoma, monoclonal gammopathy of undetermined significance
Case reports
Microscopic (histologic) description
  • Histiocytes filled with nonbirefringent eosinophilic crystals
  • Lymphocytes and plasma cells also present
Microscopic (histologic) images

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Eosinophilic histiocytes

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Immunoglobulin stains

Positive stains
  • Crystals are typically monoclonal, immunoreactive with kappa or lambda light chain and gamma heavy chain
  • CD68+ histiocytes
Electron microscopy description

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Dense crystals