Oral cavity & oropharynx

Other nonneoplastic

Ephelis



Last author update: 1 April 2013
Last staff update: 22 August 2022

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PubMed Search: Ephelis oral cavity

Charu Thakral, M.D.
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Cite this page: Thakral C. Ephelis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/oralcavityephelis.html. Accessed March 28th, 2024.
Definition / general
  • Also called freckle
  • Solitary melanotic macules, usually of lower lip
  • More common in women; associated with Peutz-Jeghers syndrome
Case reports
Clinical images

Images hosted on other servers:

55 year old woman

60 year old man

26 year old woman

37 year old woman

Microscopic (histologic) description
  • Hyperpigmentation of basal layer with elongation of rete ridges
Microscopic (histologic) images

Images hosted on other servers:

Keratinocytes (fig d)

Differential diagnosis
  • Melanoacanthoma:
    • Melanocytes mixed with keratinocytes
  • Melanosis:
    • Pigmented patches in hard palate or gingiva
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