Reviewer: Charu Thakral, M.D. (see Reviewers page)
Revised: 16 June 2013, last major update March 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
- Part of spectrum of reactive mucocutaneous disorders with maculopapular vesiculobulbous eruptions that includes erythema multiforme (EM- minor and major), Stevens-Johnson Syndrome (SJS, if more mucosal involvement and epidermal necrosis) and toxic epidermal necrolysis (TEN)
- Due to cancer, collagen vascular disorder, drugs, infection
- Oral erythema multiforme: variant with only oral lesions and no skin involvement
21 year old woman:
Irregular lip uclerations & buccal mucosal
23 year old woman:
40 year old man:
- Necrotic keratinocytes, spongiosis, basal layer liquefaction, dermal edema, perivascular or interface lymphocytes
End of Oral cavity > Dermatologic conditions > Erythema multiforme
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