Oral cavity
Dermatologic conditions
Erythema multiforme

Author: Charu Thakral, M.D. (see Authors page)

Revised: 18 April 2018, last major update March 2013

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Erythema multiforme[TI] oral[TIAB]

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Cite this page: Thakral, C. Erythema multiforme. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavityerythemamultiforme.html. Accessed January 24th, 2019.
Definition / general
  • Part of spectrum of reactive mucocutaneous disorders with maculopapular vesiculobulbous eruptions that includes erythema multiforme (EM - minor and major), Stevens-Johnson syndrome (SJS, if more mucosal involvement and epidermal necrosis) and toxic epidermal necrolysis (TEN)
  • Due to cancer, collagen vascular disorder, drugs, infection
  • Oral erythema multiforme: variant with only oral lesions and no skin involvement
Case reports
Clinical images

Images hosted on other servers:

21 year old woman:

Irregular lip uclerations and buccal mucosal


23 year old woman:

Palatal ulcerations


40 year old man:

Hemorrhagic bullae

Target lesions

Microscopic (histologic) description
  • Necrotic keratinocytes, spongiosis, basal layer liquefaction, dermal edema, perivascular or interface lymphocytes
Microscopic (histologic) images

Images hosted on other servers:

Erythema multiforme