Oral cavity
Other benign tumors / conditions
Focal epithelial hyperplasia

Topic Completed: 1 May 2013

Revised: 31 January 2019

Copyright: (c) 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Focal epithelial hyperplasia[TIAB] oral cavity[mh]

Charu Thakral, M.D.
Page views in 2019: 3,409
Page views in 2020 to date: 403
Cite this page: Thakral C Focal epithelial hyperplasia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavityfocalepithelialhyperplasia.html. Accessed February 18th, 2020.
Definition / general
  • Also called Heck disease
  • Discrete, recurrent papillary lesions on oral mucosa in Native American and Eskimo children, associated with HPV 1, 13, 32 (Eur J Dermatol 2011;21:396)
Case reports
Clinical images

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Slightly elevated

Multiple lesions

Lesions on tongue and lip

Gross description
  • Well circumscribed, sessile and pale elevation of buccal mucosa
Microscopic (histologic) description
  • Balloon cells in Malpighian layers, localized areas of mucosal epithelial hyperplasia with marked acanthosis and parakeratosis
Microscopic (histologic) images

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Typical nuclear changes

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