Oral cavity & oropharynx
Follicular dendritic cell tumor

Topic Completed: 1 November 2013

Revised: 24 May 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Follicular dendritic cell tumor oral

Nat Pernick, M.D.
Page views in 2018: 187
Page views in 2019 to date: 70
Cite this page: Pernick N. Follicular dendritic cell tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavityfolliculardendriticcelltumor.html. Accessed June 25th, 2019.
Definition / general
  • Rare tumor of oral cavity (< 30 cases reported) of antigen presenting cells of B cell follicles of lymphoid organs
  • Often misdiagnosed
  • 40% recur, 25% metastasize, most commonly to lung, liver, peritoneum and lymph nodes; mortality of 17%
  • Sites: tonsil, palate
Case reports
Microscopic (histologic) description
  • Sheets, whorls and storiform arrays of spindled and syncytial appearing cells with eosinophilic cytoplasm, oval nuclei, fine chromatin, small nucleoli and occasional nuclear pseudoinclusions
  • Also multinucleated forms; may have irregular pseudovascular spaces; cohesive growth; sharp interface with fibrous stroma; marked atypia, high mitotic rate with atypical mitotic figures
  • Background lymphocytic infiltrate with focal prominent perivascular cuffing; variable necrosis
Positive stains
Negative stains
Electron microscopy description
  • Long, complex, occasionally interdigitating cell processes joined by desmosomes
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