Oral cavity
Congenital anomalies
Fordyce disease / granules

Author: Charu Thakral, M.D. (see Authors page)

Revised: 13 April 2018, last major update January 2013

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Fordyce (disease OR granules) oral

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Cite this page: Thakral, C. Fordyce disease / granules. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavityfordyce.html. Accessed January 19th, 2019.
Definition / general
  • Common; ectopic sebaceous glands within oral cavity (Ann Dermatol 2012;24:103)
  • May be hyperplastic and nodular
  • Appear as rice-like, yellow-white, asymptomatic 1 - 3 mm papules that remain constant throughout life
  • Neoplastic transformation very rare but reported; association with HNPCC also reported (Gut 2005;54:1279)
  • Buccal mucosa (often bilateral), upper lip vermilion border, mandibular retromolar pad and tonsillar areas
Clinical images

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Yellow-white papules

Microscopic (histologic) description
  • Similar to normal sebaceous glands of skin but lack hair follicles and almost always lack ductal communication with surface
Microscopic (histologic) images

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Sebaceous glands in dermis of lip

Fordyce granules