Oral cavity
Other malignancies

Author: Nat Pernick, M.D. (see Authors page)

Revised: 10 May 2018, last major update November 2013

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Oral cavity liposarcoma

Cite this page: Pernick, N. Liposarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavityliposarcoma.html. Accessed September 22nd, 2018.
Definition / general
  • Rare; median age 51 years
  • Most commonly in buccal mucosa, tongue and soft tissue overlying mandible
  • Most common subtype is well differentiated liposarcoma
  • May recur locally but no deaths due to disease in one study (Mod Pathol 2002;15:1020)
  • Tumors 5 cm or larger are more likely to recur
  • Complete local excision, careful followup
Gross description
  • Mean 4 cm (range 1 - 6 cm)
Microscopic (histologic) description
  • Usually well differentiated, myxoid or dedifferentiated
  • Lipoblasts more common than at other sites
Dedifferentiated liposarcoma
Definition / general:
Myxoid liposarcoma
Case reports:
Well differentiated liposarcoma
Definition / general:
  • < 20 cases reported
  • High recurrence rate but long survival and minimal tendency for metastases

Case reports:
Gross description:
  • Multinodular mass, 2.5 cm

Microscopic (histologic) description:
  • Ill defined tumor with infiltrating borders, composed of mature adipose tissue with occasional lipoblasts
  • Focal spindle cells and pleomorphic lipoblasts; no mitotic figures

Positive stains:
Negative stains:
  • Muscle specific markers