Oral cavity
Other benign tumors / conditions

Topic Completed: 1 November 2013

Revised: 1 February 2019

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PubMed Search: Paraganglioma[TIAB] oral

Nat Pernick, M.D.
Page views in 2018: 252
Page views in 2019 to date: 205
Cite this page: Pernick N Paraganglioma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavityparaganglioma.html. Accessed October 18th, 2019.
Definition / general
  • For all sites, 10% are malignant; may be less in head and neck
Radiology images

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Xray: mass at base of tongue

Case reports
Microscopic (histologic) description
  • Submucosal growth of nests ("Zellballen") of uniform polygonal cells (chief cells) with abundant eosinophilic granular cytoplasm and large, regular, central nuclei
  • Surrounded by cytoplasmic processes of elongated sustentacular cells in fibrovascular stroma; no mitotic figures, no anaplasia, no necrosis and no invasion
Microscopic (histologic) images

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Nests of chief cells (fig 2A)

Positive stains
Electron microscopy description
  • Chief cells with large numbers of mitochondria, 100 - 200 nm neurosecretory granules
Electron microscopy images

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Neurosecretory granules (fig 2B)

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