Oral cavity
Other benign tumors / conditions

Topic Completed: 1 November 2013

Revised: 1 February 2019

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PubMed Search: Plasmacytosis oral

Nat Pernick, M.D.
Page views in 2018: 339
Page views in 2019 to date: 206
Cite this page: Pernick N Plasmacytosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavityplasmacytosis.html. Accessed October 18th, 2019.
Definition / general
  • No effective treatment
Gross description
  • Cobblestone or warty appearing mucosa, often at multiple sites
Microscopic (histologic) description
  • Dense subepithelial plasmacytosis with overlying psoriasiform epithelial hyperplasia
  • Plasma cells are mature but diffusely infiltrative
  • Polyclonal immunoglobulins
Differential diagnosis
  • Plasmacytoma: morphologically similar but monoclonal immunoglobulins
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