Oral cavity
Minor salivary gland tumors / lesions
Polymorphous low grade adenocarcinoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 27 April 2018, last major update November 2013

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Polymorphous low grade adenocarcinoma[TI] minor salivary glands

Cite this page: Pernick, N. Polymorphous low grade adenocarcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavityplga.html. Accessed July 22nd, 2018.
Definition / general
  • Usually palate; second most common tumor at this location after adenoid cystic carcinoma
  • Median age 54 years, range 22 - 71 years and 2/3 women
  • 30% recur, nodal metastases in 15%, 10% have distant metastases or tumor related death (Am J Surg Pathol 2000;24:1319)
Microscopic (histologic) description
  • Nonencapsulated
  • Uniform plump columnar cells with bland nuclei with diverse growth patterns (tubular, cribriform, papillary, solid, fascicular, microcystic, single file, pseudoadenoid cystic [without true lumens], strand-like, mixed)
  • Perineural invasion common around small nerves; infiltrative borders; up to 12 mitotic figures per 10 HPF; rare tumor necrosis
Positive stains