Oral cavity
Other benign tumors / conditions
Pyogenic granuloma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 April 2018, last major update November 2013

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Pyogenic granuloma oral cavity[mh]

Cite this page: Pernick, N. Pyogenic granuloma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavitypyogenicgranuloma.html. Accessed December 13th, 2018.
Definition / general
  • Also called lobular capillary hemangioma, pregnancy tumor
  • Most common tumor of gingiva
  • Affects gingiva (usually maxilla) of children, young adults and pregnant women; associated with gingivitis
  • Form of capillary hemangioma that regresses after pregnancy or undergoes fibrous maturation to resemble a fibroma; may be reactive (Am J Surg Pathol 1980;4:470)
  • Excision
Gross description
  • Elevated, dark red lesion, variable ulceration
Microscopic (histologic) description
  • Pedunculated lesion composed of granulation type tissue separated by bands of connective tissue
  • Covering epithelium almost meets at base of lesion; has lobular arrangement of capillaries at base
  • Lobules consist of discrete clusters of endothelial cells with indistinct to prominent lumina
  • Superficial lesion may have secondary changes including stromal edema, capillary dilation, inflammation and granulation tissue reaction
Differential diagnosis