Table of ContentsDefinition / general | Prognostic factors | Microscopic (histologic) description | Differential diagnosis
Cite this page: Pernick N Squamous cell carcinoma - tonsil. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavityscctonsil.html. Accessed May 27th, 2020.
Definition / general
- Common site of intraoral squamous cell carcinoma in U.S.
- High rate of nodal metastases, usually to ipsilateral digastric, middle and lower jugular, posterior cervical triangle lymph nodes
- Nodal metastases may be cystic and have bland histology
- Tumors in patients under 40 years old are associated with HPV 16 DNA by PCR, with higher Ki67 and lower p53 staining score (Am J Surg Pathol 2003;27:1463)
- Poor prognostic factors: age < 40 years, large size and nodal metastases
Microscopic (histologic) description
- Often undifferentiated and solid
- HPV positive tumors tend to have nonkeratinizing basal cell morphology
- Branchial cyst
- Branchiogenic carcinoma
- Nasopharyngeal carcinoma