Oral cavity
Other benign tumors / conditions
Solitary fibrous tumor

Topic Completed: 1 November 2013

Revised: 4 February 2019

Copyright: (c) 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Solitary fibrous tumor oral cavity

Nat Pernick, M.D.
Page views in 2018: 893
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Cite this page: Pernick N Solitary fibrous tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavitysft.html. Accessed October 21st, 2019.
Definition / general
  • Rare, < 50 cases reported; mean age 56 years
  • Slow growing, asymptomatic, submucosal tumor
  • Benign; no recurrence or metastases reported (similar behavior to other sites)
  • No associated systemic manifestations reported with oral cavity tumors
  • Sites: usually buccal mucosa, also tongue and lower lip; more likely on left side of mouth
  • References: Am J Surg Pathol 2001;25:900
Gross description
  • 1 - 4 cm, well circumscribed, round / oval, smooth surface
Microscopic (histologic) description
  • Well circumscribed tumor composed of hypercellular and hypocellular collagenous zones with haphazardly arranged, bland spindle and ovoid cells between thin and thick collagen fibers
  • Prominent hemangiopericytoma-like vascular pattern, perivascular hyalinization
  • Variable myxoid stromal change, focal fascicular or storiform patterns of spindle cells, smooth muscle-like cells with blunt ended nuclei, epithelioid cells, mitotic activity (up to 2 per 10 HPF), stromal multinucleated giant cells and mast cells
  • Occasional encapsulation, nuclear pseudoinclusions; no atypical mitotic figures, no necrosis
Microscopic (histologic) images

Contributed by Dr. Bushra Sikandar




60 year old man with circumscribed encapsulated solid lobulated mass over soft palate. Clinically, it resembled neurofibroma.

On H&E, a well circumscribed lesion comprising of interlacing bundles of elongated cells (arranged in forms of haphazard fascicles having wavy hyperchromatic nuclei with inconspicuous nucleoli) was examined. Interspersed stroma showed dense collagen bundles.

CD34 and BCL2: positive
S-100 and ASMA: negative
Positive stains
Differential diagnosis
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