Oral cavity
Other benign tumors / conditions
Solitary fibrous tumor

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 23 April 2018, last major update November 2013

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PubMed Search: Solitary fibrous tumor oral cavity
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Cite this page: Pernick, N. Solitary fibrous tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavitysft.html. Accessed January 24th, 2019.
Definition / general
  • Rare, < 50 cases reported; mean age 56 years
  • Slow growing, asymptomatic, submucosal tumor
  • Benign; no recurrence or metastases reported (similar behavior to other sites)
  • No associated systemic manifestations reported with oral cavity tumors
  • Sites: usually buccal mucosa, also tongue and lower lip; more likely on left side of mouth
  • References: Am J Surg Pathol 2001;25:900
Gross description
  • 1 - 4 cm, well circumscribed, round / oval, smooth surface
Microscopic (histologic) description
  • Well circumscribed tumor composed of hypercellular and hypocellular collagenous zones with haphazardly arranged, bland spindle and ovoid cells between thin and thick collagen fibers
  • Prominent hemangiopericytoma-like vascular pattern, perivascular hyalinization
  • Variable myxoid stromal change, focal fascicular or storiform patterns of spindle cells, smooth muscle-like cells with blunt ended nuclei, epithelioid cells, mitotic activity (up to 2 per 10 HPF), stromal multinucleated giant cells and mast cells
  • Occasional encapsulation, nuclear pseudoinclusions; no atypical mitotic figures, no necrosis
Microscopic (histologic) images

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Contributed by Dr. Bushra Sikandar, The Dow University of Health and Sciences (Pakistan):




Positive stains
Differential diagnosis