Oral cavity
Minor salivary gland tumors / lesions
Signet ring cell adenocarcinoma

Topic Completed: 1 November 2013

Revised: 4 February 2019

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PubMed Search: Signet ring cell adenocarcinoma minor salivary glands
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Cite this page: Pernick N Signet ring cell adenocarcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavitysignetringcell.html. Accessed March 18th, 2019.
Definition / general
  • Rare subtype of adenocarcinoma (2% of primary minor salivary gland malignancies)
  • Appear to be slow growing with favorable outcome, although data is limited (Am J Surg Pathol 2004;28:89)
Microscopic (histologic) description
  • Noncircumscribed tumor composed of bland, mucin containing signet ring cells that invade in narrow parallel strands, with scattered small nests or individually infiltrating cells
  • No solid, cribriform or papillary components; often perineural invasion; minimal ductal differentiation, no angiolymphatic invasion
Positive stains
Negative stains
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