Oral cavity
Minor salivary gland tumors / lesions
Signet ring cell adenocarcinoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 27 April 2018, last major update November 2013

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Signet ring cell adenocarcinoma minor salivary glands

Cite this page: Pernick, N. Signet ring cell adenocarcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavitysignetringcell.html. Accessed November 18th, 2018.
Definition / general
  • Rare subtype of adenocarcinoma (2% of primary minor salivary gland malignancies)
  • Appear to be slow growing with favorable outcome, although data is limited (Am J Surg Pathol 2004;28:89)
Microscopic (histologic) description
  • Noncircumscribed tumor composed of bland, mucin containing signet ring cells that invade in narrow parallel strands, with scattered small nests or individually infiltrating cells
  • No solid, cribriform or papillary components; often perineural invasion; minimal ductal differentiation, no angiolymphatic invasion
Positive stains
Negative stains