Table of ContentsDefinition / general | Microscopic (histologic) description | Positive stains | Negative stains | Differential diagnosis
Cite this page: Pernick N Signet ring cell adenocarcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavitysignetringcell.html. Accessed March 18th, 2019.
Definition / general
- Rare subtype of adenocarcinoma (2% of primary minor salivary gland malignancies)
- Appear to be slow growing with favorable outcome, although data is limited (Am J Surg Pathol 2004;28:89)
Microscopic (histologic) description
- Noncircumscribed tumor composed of bland, mucin containing signet ring cells that invade in narrow parallel strands, with scattered small nests or individually infiltrating cells
- No solid, cribriform or papillary components; often perineural invasion; minimal ductal differentiation, no angiolymphatic invasion