Smokeless tobacco keratosis
Reviewer: Charu Thakral, M.D. (see Reviewers page)
Revised: 16 June 2013, last major update March 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
- Occurs in users of smokeless tobacco (snuff) or tobacco chewers
- Severity related to length of exposure and tobacco brand
- Reversible with cessation of use (Arch Pathol Lab Med 2004;128:e17)
- Filmy, gray-white opalescence at areas of contact with tobacco
- Parakeratosis or hyperorthokeratosis with parakeratin spires ("chevrons"), acanthosis, mild chronic inflammation and PAS+ marked hyalin deposition resembling amyloid
and acanthosis, diffuse hyalinization
of lamina propria, PAS+ hyaline material
- Hyalinosis cutis et mucosae: deposition begins around vessels, eccrine glands and epithelial-stromal interface, then fills entire dermis of all oral mucosa, tongue, pharynx, larynx and vocal cords
End of Oral cavity > Dermatologic conditions > Smokeless tobacco keratosis
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