Oral cavity
Other benign tumors / conditions
Spitz nevus

Topic Completed: 1 November 2013

Revised: 1 February 2019

Copyright: (c) 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Spitz nevus oral

Nat Pernick, M.D.
Page views in 2018: 173
Page views in 2019 to date: 251
Cite this page: Pernick N Spitz nevus. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavityspitz.html. Accessed September 19th, 2019.
Definition / general
  • Also called spindle and epithelial cell nevus
Case reports
Gross description
  • Raised lesion
Microscopic (histologic) description
  • Cellular proliferation centered in subepithelial connective tissue with junctional component
  • Tumor cells are spindled and mixed with polygonal epithelial cells, some multinucleated
  • Cytoplasm of both cells is eosinophilic with no / sparse melanin granules
  • Moderate nuclear atypia; no / scant mitotic figures
  • Prominent pseudoepitheliomatous hyperplasia with frequent mitotic figures in elongated strands of squamous cells
Positive stains
  • Melanocytes: S100; pseudoepitheliomatous squamous cells - keratin
Negative stains
Differential diagnosis
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