Oral cavity
Other benign tumors / conditions
Spitz nevus

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 April 2018, last major update November 2013

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Spitz nevus oral

Cite this page: Pernick, N. Spitz nevus. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavityspitz.html. Accessed August 17th, 2018.
Definition / general
  • Also called spindle and epithelial cell nevus
Case reports
Gross description
  • Raised lesion
Microscopic (histologic) description
  • Cellular proliferation centered in subepithelial connective tissue with junctional component
  • Tumor cells are spindled and mixed with polygonal epithelial cells, some multinucleated
  • Cytoplasm of both cells is eosinophilic with no / sparse melanin granules
  • Moderate nuclear atypia; no / scant mitotic figures
  • Prominent pseudoepitheliomatous hyperplasia with frequent mitotic figures in elongated strands of squamous cells
Positive stains
  • Melanocytes: S100; pseudoepitheliomatous squamous cells - keratin
Negative stains
Differential diagnosis