Oral cavity

Topic Completed: 1 July 2012

Revised: 31 January 2019

Copyright: (c) 2001-2019, PathologyOutlines.com, Inc.

PubMed Search: Syphilis[TI] oral[TI]

Patricia DeVilliers D.D.S., M.S.
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Cite this page: DeVilliers P Syphilis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavitysyphilis.html. Accessed April 6th, 2020.
Definition / general
  • Primary stage called chancre, has painless ulcerations
  • Secondary stage has mucous patches along oral mucosa
  • Tertiary stage is characterized by destruction of bone called gumma
Microscopic (histologic) description
  • Granulomas with giant cells, plasma cells, vascular changes
  • Immunoperoxidase stain for Treponema pallidum demonstrates numerous spirochetes
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