Oral cavity
Infectious
Syphilis

Author: Patricia DeVilliers, DDS, MS (see Authors page)

Revised: 16 April 2018, last major update July 2012

Copyright: (c) 2001-2018, PathologyOutlines.com, Inc.

PubMed Search: Syphilis[TI] oral[TI]

Cite this page: DeVilliers, P. Syphilis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavitysyphilis.html. Accessed October 17th, 2018.
Definition / general
  • Primary stage called chancre, has painless ulcerations
  • Secondary stage has mucous patches along oral mucosa
  • Tertiary stage is characterized by destruction of bone called gumma
Microscopic (histologic) description
  • Granulomas with giant cells, plasma cells, vascular changes
  • Immunoperoxidase stain for Treponema pallidum demonstrates numerous spirochetes