Reviewer: Patricia DeVilliers, D.D.S., M.S. (see Reviewers page)
Revised: 3 October 2012, last major update July 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.
● Primary stage called chancre, has painless ulcerations
● Secondary stage has mucous patches along oral mucosa
● Tertiary stage is characterized by destruction of bone called gumma
● Granulomas with giant cells, plasma cells, vascular changes
● Immunoperoxidase stain for Treponema pallidum demonstrates numerous spirochetes
End of Oral cavity > Infectious > Syphilis
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