General
=========================================================================

• Rare, autosomal dominant disease characterized by large white plaques in oral mucosa with hyperkeratosis, acanthosis and perinuclear eosinophilic condensation on superficial layers
  
• Dyskeratotic hyperplasia of mucous membranes, affecting 1 in 200,000 people

Case reports
=========================================================================

• 13 and 15 year old sisters (An Bras Dermatol 2011;86:S39)
  
• 21 year old man with no familial involvement (J Dent Res Dent Clin Dent Prospects 2009;3:70)
  
• 33 year old man with 13 year history of plaques on buccal mucosa and tongue (Dermatol Online J 2008;14(5):16)

Clinical images
=========================================================================

Ventral surface of tounge

Vestibular mucosa

21 year old man

 

33 year old man

Micro images
=========================================================================

Hyperparakeratosis and acanthosis

Vacuolization in keratinocytes

33 year old man

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).