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Ovary - nontumor

Non-neoplastic cysts/other

Massive edema of ovary

Reviewer: Shahid Islam, M.D., (see Reviewers page)
Revised: 5 June 2012, last major update June 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.


● Tumor-like enlargement of ovary due to edema fluid
● First described in 1969 (Obstet Gynecol 1969;34:564)
● Patients present with pain, abdominal mass, menstrual irregularities, virilization, precocious puberty, Meig’s syndrome (with ascites and pleural effusion, eMedicine)
● May be due to partial torsion of mesovarium leading to interference of venous / lymphatic drainage
● Usually young women
● Right-sided involvement is more common

Gross description

● Marked ovarian enlargement, watery cut surface, no necrosis

Micro description

● Marked edema of stroma surrounding follicles and clusters of luteinized cells
● Stroma around vessels and in superficial cortical zone is normal
● Variable stromal luteinization

Micro images

Clusters of lutein cells lie in the edematous stroma

Loose stroma with occasional inflammatory cells #1; #2

Differential diagnosis

Fibroma: circumscribed, tumor cells replace ovarian architecture
Krukenberg tumor: usually bilateral, signet ring cells present

Additional references

Am J Surg Pathol 1979;3:11, Arch Pathol Lab Med 1979;103:42

End of Ovary - nontumor > Non-neoplastic cysts/other > Massive edema of ovary

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