Ovary - nontumor
Nonneoplastic cysts / other
Massive edema of ovary

Author: Shahid Islam, M.D., (see Authors page)

Revised: 5 October 2018, last major update June 2012

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: (Massive edema [title]) ovary

Cite this page: Islam, S. Massive edema of ovary. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarymassiveedema.html. Accessed October 22nd, 2018.
Definition / general
  • Tumor-like enlargement of ovary due to edema fluid
  • First described in 1969 (Obstet Gynecol 1969;34:564)
  • Patients present with pain, abdominal mass, menstrual irregularities, virilization, precocious puberty, Meigs syndrome (with ascites and pleural effusion, eMedicine: Meigs Syndrome)
  • May be due to partial torsion of mesovarium leading to interference of venous / lymphatic drainage
  • Usually young women
  • Right sided involvement is more common
Gross description
  • Marked ovarian enlargement, watery cut surface, no necrosis
Microscopic (histologic) description
  • Marked edema of stroma surrounding follicles and clusters of luteinized cells
  • Stroma around vessels and in superficial cortical zone is normal
  • Variable stromal luteinization
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Dr. Joseph Christopher Castillo

Clusters of lutein cells lie in the edematous stroma

Images hosted on other servers:

Loose stroma with occasional inflammatory cells

Differential diagnosis
  • Fibroma: circumscribed, tumor cells replace ovarian architecture
  • Krukenberg tumor: usually bilateral, signet ring cells present