Home
Chapter Home
Jobs
Conferences
Fellowships
Books
Advertisement
Ovary - nontumor
Gonadal dysgenesis
Female pseudohermaphroditism
Reviewer: Mohiedean Ghofrani, M.D., (see Reviewers page)
Revised: 28 December 2011, last major update December 2011
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.
General
=========================================================================
● A disorder of sex development (DSD) with female genotype (46,XX), female internal phenotype (two ovaries) but variable degrees of virilization
Terminology
=========================================================================
● In 2006 the International Consensus Conference on Intersex recommended using the designation "46,XX DSD" instead of the potentially pejorative and confusing term "female pseudohermaphroditism"
Laboratory
=========================================================================
● Serum steroid measurements can confirm or rule out congenital adrenal hyperplasia in most 46,XX DSD cases
Etiology
=========================================================================
● Most virilized 46,XX infants have congenital adrenal hyperplasia (CAH)
● Non-CAH etiologies include gestational hyperandrogenism
Clinical Features
=========================================================================
● In CAH, depending on the site of the steroid biosynthesis defect, there may be under- or over-production of mineralcorticoid, resulting in imbalances in serum electrolytes and blood pressure
Additional references
=========================================================================
End of Ovary - nontumor > Gonadal dysgenesis > Female pseudohermaphroditism
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com
with any questions (click here for other
contact information).