Ovary - nontumor - Giant cell arteritis

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Ovary-nontumor

Inflammatory disorders

Giant cell arteritis

Reviewer: Mohiedean Ghofrani, M.D. (see Reviewers page)
Revised: 9 August 2011, last major update August 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

Definition
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● Histology of giant cell arteritis localized to the ovary

Laboratory
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● May be associated with elevated ESR
● Antineutrophilic cytoplasmic antibodies were negative in two tested patients

Epidemiology
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● Rare
● Usually elderly women

Etiology
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● Part of generalized condition or isolated

Clinical features
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● Isolated form is often incidental finding in otherwise asymptomatic woman
● Symptomatic presentation is postmenopausal woman with apparent ovarian or breast tumor, constitutional symptoms, and elevated sedimentation rate (Medicine (Baltimore) 2000;79:349)
● May be associated with systemic manifestations such as polymyalgia rheumatica or temporal arteritis

Prognostic factors
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● Of two patients who received no therapy, one had a thoracic aortic aneurysm 5 years after diagnosis, and the other was alive without symptoms after 17 years of follow up (Am J Surg Pathol 1986;10:696)

Treatment
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● Prednisone has been reported to improve symptoms and decrease ESR (South Med J 2005;98:469)
● Treatment is probably unnecessary in asymptomatic patients, but patients should be followed with regular ESR measurements (Int J Gynecol Pathol 1991;10:51)

Micro images
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Epithelioid granulomas (arrows) of ovarian hilar arteries

End of Ovary-nontumor > Inflammatory disorders > Giant cell arteritis

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