Giant cell arteritis
Reviewer: Mohiedean Ghofrani, M.D. (see Reviewers page)
Revised: 9 August 2011, last major update August 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.
● Histology of giant cell arteritis localized to the ovary
● May be associated with elevated ESR
● Antineutrophilic cytoplasmic antibodies were negative in two tested patients
● Usually elderly women
● Part of generalized condition or isolated
● Isolated form is often incidental finding in otherwise asymptomatic woman
● Symptomatic presentation is postmenopausal woman with apparent ovarian or breast tumor, constitutional symptoms, and elevated sedimentation rate (Medicine (Baltimore) 2000;79:349)
● May be associated with systemic manifestations such as polymyalgia rheumatica or temporal arteritis
● Of two patients who received no therapy, one had a thoracic aortic aneurysm 5 years after diagnosis, and the other was alive without symptoms after 17 years of follow up (Am J Surg Pathol 1986;10:696)
● Prednisone has been reported to improve symptoms and decrease ESR (South Med J 2005;98:469)
● Treatment is probably unnecessary in asymptomatic patients, but patients should be followed with regular ESR measurements (Int J Gynecol Pathol 1991;10:51)
Epithelioid granulomas (arrows) of ovarian hilar arteries
End of Ovary-nontumor > Inflammatory disorders > Giant cell arteritis
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