Ovary - nontumor
Infectious disorders
Granulomatous inflammation

Author: Mohiedean Ghofrani, M.D. (see Authors page)

Revised: 5 October 2018, last major update August 2011

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: "Granulomatous inflammation" ovary

Cite this page: Ghofrani, M. Granulomatous inflammation. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarynontumorgranulomatous.html. Accessed October 22nd, 2018.
Definition / general
  • Necrotizing or nonnecrotizing granulomatous inflammation of the ovary
  • Cortical granulomas are common incidental findings with uncertain clinical significance
  • Primary ovarian tuberculosis and other primary ovarian granulomas are uncommon
  • Frequency of secondary ovarian granulomas depends on primary cause
Clinical features
  • Often an incidental finding or part of a systemic granulomatous disorder
Case reports
  • In secondary cases, treat primary cause
Gross description
  • May present as a mass and simulate a tumor
Microscopic (histologic) description
  • Tuberculosis is typically confined to the cortex
Microscopic (histologic) images

Images hosted on PathOut server:

AFIP images:

Actinomycosis: ovary is replaced by tissue that was soft and yellow; characteristic sulfur granule surrounded by polymorphonuclear leukocytes is on the right

Actinomycosis: histiocytes have abundant bubbly gray pink cytoplasm and resemble signet ring cells

Actinomycosis: histiocytes are mucicarmine+

Images hosted on other servers:

Central suppuration
and surrounding
giant cells in
Crohn's disease


Actinomycosis: tubo-ovarian

Positive stains
  • AFB is typically positive in tuberculous oophoritis
Additional references