Other nonneoplastic
Hyperreactio luteinalis

Topic Completed: 1 August 2011

Minor changes: 5 May 2020

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PubMed Search: Hyperreactio luteinalis

Mohiedean Ghofrani, M.D.
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Cite this page: Ghofrani M. Hyperreactio luteinalis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarynontumorhyperreactio.html. Accessed September 23rd, 2020.
Definition / general
  • Bilateral, ovarian enlargement due to multiple, luteinized follicle cysts
  • Rare
  • Associated with hydatidiform mole, choriocarcinoma, fetal hydrops due to Rh sensitization and multiple gestations
  • Rarely seen in uncomplicated, single pregnancy
  • Due to hCG stimulation or hypersensitivity to hCG
Clinical features
  • Usually no symptoms, may have pain from hemorrhage; rarely ascites
  • Virilization in 15% of mothers but not female infants in cases without gestational trophoblastic disease
Prognostic factors
Case reports
Gross description
  • Multiple, bilateral thin walled cysts, filled with clear or hemorrhagic fluid
Gross images

AFIP images

Both ovaries are
enlarged by
multiple thin
walled cysts

Microscopic (histologic) description
  • Follicular cysts with luteinization of theca interna or granulosa cells, edema of theca layer and stroma
Microscopic (histologic) images

AFIP images

Two cysts are lined
by luteinized granulosa
cells overlying luteinized
theca cells

There is prominent
edema in the
luteinized theca
cell layer

Ovarian stroma is markedly edematous

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