Ovary - nontumor
Nonneoplastic cysts / other
Hyperreactio luteinalis

Author: Mohiedean Ghofrani, M.D. (see Authors page)

Revised: 5 October 2018, last major update August 2011

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Hyperreactio luteinalis

Cite this page: Ghofrani, M. Hyperreactio luteinalis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarynontumorhyperreactio.html. Accessed November 18th, 2018.
Definition / general
  • Bilateral, ovarian enlargement due to multiple, luteinized follicle cysts
  • Rare
  • Associated with hydatidiform mole, choriocarcinoma, fetal hydrops due to Rh sensitization and multiple gestations
  • Rarely seen in uncomplicated, single pregnancy
  • Due to hCG stimulation or hypersensitivity to hCG
Clinical features
  • Usually no symptoms, may have pain from hemorrhage; rarely ascites
  • Virilization in 15% of mothers but not female infants in cases without gestational trophoblastic disease
Prognostic factors
Case reports
Gross description
  • Multiple, bilateral thin walled cysts, filled with clear or hemorrhagic fluid
Gross images

Images hosted on PathOut server:

AFIP images:

Both ovaries are
enlarged by
multiple thin
walled cysts

Microscopic (histologic) description
  • Follicular cysts with luteinization of theca interna or granulosa cells, edema of theca layer and stroma
Microscopic (histologic) images

Images hosted on PathOut server:

AFIP images:

Two cysts are lined
by luteinized granulosa
cells overlying luteinized
theca cells

There is prominent
edema in the
luteinized theca
cell layer

Ovarian stroma is markedly edematous