Ovary - nontumor
Nonneoplastic cysts / other

Author: Mohiedean Ghofrani, M.D. (see Authors page)

Revised: 5 October 2018, last major update August 2011

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Ovary hyperthecosis [title]

Cite this page: Ghofrani, M. Hyperthecosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarynontumorhyperthecosis.html. Accessed October 22nd, 2018.
Definition / general
  • Hyperplastic ovarian stroma with clusters of luteinized stromal cells
  • Typically seen in the 6th to 7th decade, less common in reproductive age
  • Luteinized stromal cells produce androgens
Clinical features
  • Similar symptoms as polycystic ovarian syndrome but higher testosterone levels and no / fewer cysts
  • Typically patients are obese with striking virilization and insulin resistance
Case reports
Gross description
  • Uniform enlargement of both ovaries
  • Solid, yellow white cut surface
  • May have superficial cysts
Gross images

Images hosted on PathOut server:

AFIP images:

Both ovaries are enlarged; the cut surface of the left ovary is composed of firm, white tissue simulating a neoplasm

Microscopic (histologic) description
  • Scattered nests of luteinized theca cells in ovarian stroma
Microscopic (histologic) images

Images hosted on PathOut server:

AFIP images:

Numerous nests of
vacuolated, luteinized
cells are present in
the ovarian stroma

Luteinized cells have an eosinophilic, nonvacuolated cytoplasm and regular, round nuclei with prominent nucleoli

Large nodule of luteinized
cells is present within
the ovarian stroma
(nodular hyperthecosis)

Lutein cells contain abundant lipid (oil red O stain)

Images hosted on other servers:

Stromal cells are enlarged and pale staining