Ovary - nontumor
Nonneoplastic cysts / other
Stromal hyperplasia

Author: Shahid Islam, M.D. (see Authors page)

Revised: 20 September 2017, last major update May 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Ovarian stromal hyperplasia [title]

Page views in 2018: 3,230
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Cite this page: Islam, S. Stromal hyperplasia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarystromalhyperplasia.html. Accessed January 23rd, 2019.
Definition / general
  • Varying degrees of proliferation of ovarian stromal cells, potentially mimicking a neoplasm but without luteinization (stromal hyperthecosis refers to presence of luteinized cells in the stroma at a distance from the follicles)
  • Less frequently estrogenic or androgenic than stromal hyperthecosis
  • Patients may be obese, have hypertension or abnormal glucose tolerance
Gross description
  • Almost invariably bilateral, ill defined, homogeneous white yellow nodules in ovary
  • May lead to enlarged ovary
Gross images

Images hosted on PathOut server:

Ill defined, pale
yellow tissue
occupies the center
of the ovary

Microscopic (histologic) description
  • Medullary or occasionally cortical clusters of densely cellular ovarian stroma with scant collagen
  • May entirely replace ovarian architecture
  • No luteinized stromal cells but the cells are often plumper than normal postmenopausal stromal cells
  • No mitotic figures
Microscopic (histologic) images

Images hosted on PathOut server:

Ovarian medulla and
cortex of an elderly
woman are replaced
by cellular stroma

Confluent nodules
of hyperplastic
stroma occupy
the medulla

Differential diagnosis