Ovary - nontumor
Nonneoplastic cysts / other
Stromal hyperplasia


Topic Completed: 1 May 2012

Revised: 7 February 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Ovarian stromal hyperplasia [title]
Page views in 2018: 3,230
Page views in 2019 to date: 1,432
Cite this page: Islam S Stromal hyperplasia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarystromalhyperplasia.html. Accessed May 20th, 2019.
Definition / general
  • Varying degrees of proliferation of ovarian stromal cells, potentially mimicking a neoplasm but without luteinization (stromal hyperthecosis refers to presence of luteinized cells in the stroma at a distance from the follicles)
  • Less frequently estrogenic or androgenic than stromal hyperthecosis
  • Patients may be obese, have hypertension or abnormal glucose tolerance
Gross description
  • Almost invariably bilateral, ill defined, homogeneous white yellow nodules in ovary
  • May lead to enlarged ovary
Gross images

Ill defined, pale
yellow tissue
occupies the center
of the ovary

Microscopic (histologic) description
  • Medullary or occasionally cortical clusters of densely cellular ovarian stroma with scant collagen
  • May entirely replace ovarian architecture
  • No luteinized stromal cells but the cells are often plumper than normal postmenopausal stromal cells
  • No mitotic figures
Microscopic (histologic) images

Ovarian medulla and
cortex of an elderly
woman are replaced
by cellular stroma

Confluent nodules
of hyperplastic
stroma occupy
the medulla

Differential diagnosis
Back to top