Home   Chapter Home   Jobs   Conferences   Fellowships   Books

Advertisement

Ovary - nontumor

Non-neoplastic cysts/other

Stromal hyperplasia

Reviewer: Shahid Islam, M.D., (see Reviewers page)
Revised: 5 June 2012, last major update May 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Varying degrees of proliferation of ovarian stromal cells, potentially mimicking a neoplasm, but without luteinization (stromal hyperthecosis refers to presence of luteinized cells in the stroma at a distance from the follicles)
● Less frequently estrogenic or androgenic than stromal hyperthecosis
● Patients may be obese, have hypertension or abnormal glucose tolerance

Gross description
=========================================================================

● Almost invariably bilateral, ill defined, homogeneous white-yellow nodules in ovary
● May lead to enlarged ovary

Gross images
=========================================================================

Ill-defined, pale yellow tissue occupies the center of the ovary

Micro description
=========================================================================

● Medullary or occasionally cortical clusters of densely cellular ovarian stroma with scant collagen
● May entirely replace ovarian architecture
● No luteinized stromal cells, but the cells are often plumper than normal post-menopausal stromal cells
● No mitotic figures

Micro images
=========================================================================

The ovarian medulla and cortex of an elderly woman are replaced by cellular stroma


Confluent nodules of hyperplastic stroma occupy the medulla

Differential diagnosis
=========================================================================

● Stromal hyperthecosis (luteinized cells), low grade endometrial stromal sarcoma (spiral arterioles and mitotic figures present)
● Fibroma (unilateral or bilateral, cells have larger nuclei)

End of Ovary - nontumor > Non-neoplastic cysts/other > Stromal hyperplasia

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).