Ovary tumor
Other ovarian specific tumors
Female adnexal tumor of wolffian origin

Authors: Nat Pernick, M.D. (see Authors page)

Revised: 17 June 2016, last major update December 2008

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed search: female adnexal tumor of wolffian origin
Cite this page: Female adnexal tumor of wolffian origin. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorFATWO.html. Accessed October 28th, 2016.
Definition / General
  • Originally described as arising from broad ligament, also ovary, fallopian tube and retroperitoneum
  • Not a sex-cord stromal tumor since wolffian / mesonephric origin, but resembles them
  • No stromal cells of steroid hormone secreting type, no hormonal manifestations
  • Wide age range (15-81 years)
  • Usually benign, rarely malignant with metastases to omentum, liver and lung
  • References: Am J Surg Pathol 2003;27:178
Case Reports
Gross Description
  • Solid or solid / cystic, smooth surface, yellow-tan, usually unilateral, 1-20 cm, focal hemorrhage and necrosis
Gross Images

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Lobulated section surfaces

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Tumor of broad ligament and mesosalpinx

Micro Description
  • Epithelial cells form cystic structures, hollow or solid tubules and diffuse sheets
  • Sieve-like on low power; tubules outlined by well-defined basement membrane
  • Cells are low cuboidal with minimal eosinophilic cytoplasm, oval hyperchromatic nuclei, finely granular chromatin, no atypia, no / rare mitotic activity
  • Hemorrhage and necrosis may be present
  • PAS+ basement membranes are prominent around epithelial aggregates
Micro Images

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Sieve-like pattern (top); solid pattern (bottom)

Hollow tubular pattern

Bland nuclear features

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H&E, CAM 5.2, vimentin

Positive Stains
  • CD10, CAM5.2, vimentin and variable EMA
Negative Stains
  • Mucin, B72.3, CEA, S100 and inhibin alpha (may be weak / focal positive)
Electron Microscopy Description
  • Thick layer of basal lamina surrounding tubules
  • Prominent desmosomes, distinct junctional complexes
  • Irregular nuclei, prominent nucleoli; cilia present
Electron Microscopy Images

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Thick basement membrane, desmosomes

Differential Diagnosis