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Table of Contents
Definition / general | Pathophysiology | Clinical features | Case reports | Treatment | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Electron microscopy description | Differential diagnosisCite this page: Gupta N Adenoid cystic and basaloid carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumoradenoidcystic.html. Accessed March 22nd, 2019.
Definition / general
- First described in 1995 by Eichhorn and Scully (Mod Pathol 1995;8:731)
- Very rare ovarian tumors
- Postulated to be of surface epithelial origin
- Adenoid cystic carcinomas are more aggressive than basaloid carcinomas, present at older age
Pathophysiology
- Postulated origin is through metaplasia of coelomic / surface epithelium
- Rarely may be teratomatous origin
Clinical features
- Abdominal pain, unilateral abdominal mass
- Adenoid cystic carcinoma: mean age 67 years, range 60 to 78 years
- Basaloid carcinoma: mean age 49 years, range 19 to 65 years
Case reports
- 23 year old woman (Arch Pathol Lab Med 2000;124:1529)
- 45 year old woman (Mod Pathol 1996;9:413)
Treatment
- Unilateral salpingo-oophorectomy (Mod Pathol 1996;9:413) with or without adjuvant radiotherapy (Int J Radiat Oncol Biol Phys 2000;46:551)
- Chemotherapy for metastatic disease
Gross description
- Unilateral
- Encapsulated
- Solid with small cystic spaces (Mod Pathol 1995;8:731)
Microscopic (histologic) description
- Small uniform and basaloid cells in tubular pattern with cribriform and focal solid areas
- Multiple round hyaline stromal cylinders
- Minimal pleomorphism or mitotic activity, no necrosis
- With myoepithelial differentiation, tumor cells are ovoid to spindled (Arch Pathol Lab Med 2000;124:1529, Mod Pathol 1996;9:413)
Microscopic (histologic) images
Images hosted on other servers:
Adenoid cystic carcinoma
Basaloid and ameloblastoma-like features
S100
GFAP
Positive stains
- Cytokeratins CAM 5.2 and AE1/3, CEA
- Peripheral cells positive for muscle-specific actin, S100, GFAP
Negative stains
- Alcain blue, alpha inhibin, ER, PR, desmin, AFP
Electron microscopy description
- Myoepithelial component shows convoluted nuclei and filamentous structures associated with dense bodies
Differential diagnosis
- Metastasis of ACC from another site (Mod Pathol 1995;8:731)
- Primary or metastatic ACC-like carcinoma (Am J Surg Pathol 1988;12:134)
- Reticular variant of a yolk-sac tumor (Blaustein's Pathology of the Female Genital Tract)
