Ovary tumor
Other tumors not specific to ovary
Angiomyolipoma

Authors: Nalini Gupta, M.D. (see Authors page)

Revised: 17 June 2016, last major update January 2014

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Angiomyolipoma ovary
Cite this page: Angiomyolipoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumoraml.html. Accessed December 5th, 2016.
Definition / General
  • Benign tumor seen mostly in kidney
  • Composed of blood vessels, smooth muscle cells and fat cells (hence the name: angio-, myo- and lip-)
  • Two types: isolated angiomyolipoma and angiomyolipoma associated with tuberous sclerosis
Epidemiology
Sites
  • Mostly in kidney
  • Rarely in other organs such as liver, colon, lung, heart, nasal cavity and oral cavity
Pathophysiology
Clinical Features
  • Increasing heaviness and mild tenderness in the iliac fossa
  • Intratumoral or retroperitoneal hemorrhage
Diagnosis
  • Scanning: ultrasound, CT and MRI
  • Final diagnosis is by histology and immunhistochemistry
Radiology Description
  • USG shows echogenic appearance due to its fat content and the presence of multiple tissue interfaces within it (Radiology 1996;198:789)
Case Reports
Treatment
  • Complete surgical resection
Gross Description
Micro Description
  • Typical case shows mixture of mature adipose tissue, tortuous thick walled blood vessels lacking elastic lamina and bundles of smooth muscle that seem to emanate from the vessel wall
Micro Images

Images hosted on other servers:

Clusters of adipocytes (fig 1)

Adipocytes, blood vessels, smooth muscle bundles (fig 2)

Angiomyolipoma
not ovary

Positive Stains
  • CD117 (cKit), progesterone receptor, desmin, actin, HMB45, vimentin
  • Also S100P
Flow Cytometry Description
  • Aneuploidy
  • Tuberous sclerosis may show mutation of TSC1 and TSC2 genes
Differential Diagnosis
  • Oxyphilic tumors are HMB45 negative