Ovary tumor
Other tumors not specific to ovary

Topic Completed: 1 January 2014

Revised: 13 February 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: angiosarcoma [title] ovary

Page views in 2018: 170
Page views in 2019 to date: 127
Cite this page: Gupta N Angiosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorangiosarcoma.html. Accessed September 22nd, 2019.
Definition / general
  • Usually premenopausal women
  • Outside ovary, common sites are head and neck, deep soft tissue
Clinical features
  • Abdominal pain and distension
  • Tumor markers CA-125, carcinoembryonic antigen, β-human chorionic gonadotropin, and α-fetoprotein are mostly normal (J Clin Oncol 2010;28:e675)
Radiology description
  • Ultrasonography and computed tomography reveal heterogeneous adnexal mass
Prognostic factors
Case reports
  • Radical surgical excision followed by various chemotherapeutic regimens
Gross description
  • Unilateral mostly in right ovary, hemorrhagic, median 13 cm
  • Solid cystic with smooth to bosselated surface
Gross images

Images hosted on other servers:

Soft, spongy, hemorrhagic cut surface

Centrally located tumor associated cyst

Yellow-white fibrous tumor

Microscopic (histologic) description
  • Anastomosing vascular spaces with slit-like lumina interspersed with solid fascicular areas
  • Pleomorphic, epithelioid to focally spindled cells, few with intracytoplasmic lumina
  • Brisk mitotic activity, necrosis, hemorrhage
  • Vascular nature often not immediately apparent, but at least focal vasoformative channels or discrete cytoplasmic vacuoles
  • Variable features: fascicular growth pattern composed of spindle cells with ovoid nuclei and ample eosinophilic cytoplasm mimicking leiomyosarcoma; reticular growth pattern resembling yolk sac tumor; features resembling clear cell carcinoma
Microscopic (histologic) images

Images hosted on other servers:

Large endothelial cells with bizarre nuclei

Vessel-like structures

Focal high grade

Arising in ovarian fibroma

Atypical mitosis



Positive stains
Negative stains
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